2323623-93-2
Chemical Structure
AS-99 free base
- CAS No.: 2323623-93-2
- Formula:C27H30F3N5O3S2
- Molecular Weight:593.68
IUPAC Name: N-((3-(3-carbamothioylphenyl)-1-(1-((trifluoromethyl)sulfonyl)piperidin-4-yl)-1H-indol-6-yl)methyl)-1-methylazetidine-3-carboxamide
InChIKey: VPQCHIWQHIOPQS-UHFFFAOYSA-N
SMILES: O=C(C1CN(C)C1)NCC2=CC3=C(C=C2)C(C4=CC=CC(C(N)=S)=C4)=CN3C5CCN(S(=O)(C(F)(F)F)=O)CC5
Biological Activity: AS-99 is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 µM, Kd= 0.89 µM) with anti-leukemic activity. AS-99 blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo[1].
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AS-99 free base | 98.57% | AS-99 is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 µM, Kd= 0.89 µM) with anti-leukemic activity. AS-99 blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo. | ||||||||||||||||||||
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Keywords
