2324-94-9
2324-94-9
Chemical Structure
Profadol hydrochloride
Synonym(s): CI-572 hydrochloride
- CAS. Nr.: 2324-94-9
- Formula:C14H22ClNO
- Molecular Weight:255.78
IUPAC Name: 3-(1-methyl-3-propylpyrrolidin-3-yl)phenol hydrochloride
InChIKey: HRCGIZACAMIMII-UHFFFAOYSA-N
SMILES: OC1=CC=CC(C2(CCC)CN(CC2)C)=C1.Cl
Biological Activity: Profadol (CI-572) hydrochloride is a potent analgesic agent. Profadol is a µ-opioid receptor (MOR) agonist. Profadol hydrochloride activates the γ-aminobutyric acid (GABA) receptors and inhibits the N-methyl-D-aspartate (NMDA) receptor. Profadol increases the mRNA and protein expression of MOR[1][2].
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Profadol hydrochloride | Profadol (CI-572) hydrochloride is a potent analgesic agent. Profadol is a µ-opioid receptor (MOR) agonist. Profadol hydrochloride activates the γ-aminobutyric acid (GABA) receptors and inhibits the N-methyl-D-aspartate (NMDA) receptor. Profadol increases the mRNA and protein expression of MOR. | |||||||||||||||||||||
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References
- [1]. Beaver WT, et al. A comparison of the analgesic effects of profadol and morphine in patients with cancer. Clin Pharmacol Ther. 1969 May-Jun;10(3):314-9. [Content Brief]
- [2]. Li Z, et al. Propofol increases µ-opioid receptor expression in SH-SY5Y human neuroblastoma cells. Mol Med Rep. 2012 Dec;6(6):1333-6. [Content Brief]
Keywords
