2387510-88-3
2387510-88-3
Chemical Structure
OD36 hydrochloride
- CAS No.: 2387510-88-3
- Formula:C16H16Cl2N4O2
- Molecular Weight:367.23
IUPAC Name: (13Z,15E)-25-chloro-14,15-dihydro-3,6-dioxa-9-aza-1(3,5)-pyrazolo[1,5-a]pyrimidina-2(1,3)-benzenacyclononaphane hydrochloride
InChIKey: VGOJZWODJXQKMN-UHFFFAOYSA-N
SMILES: ClC1=CC(C2=C3N/C(C=CN3N=C2)=N/CCOCCO4)=CC4=C1.Cl
Biological Activity: OD36hydrochloride is a RIPK2 inhibitor with an IC50 of 5.3 nM. OD36 hydrochloride is a macrocyclic inhibitor with potent binding to the ALK2 kinase ATP pocket. OD36 hydrochloride shows ALK2-directed activity with KDs of 37 nM[1][2].
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OD36 hydrochloride | OD36hydrochloride is a RIPK2 inhibitor with an IC50 of 5.3 nM. OD36 hydrochloride is a macrocyclic inhibitor with potent binding to the ALK2 kinase ATP pocket. OD36 hydrochloride shows ALK2-directed activity with KDs of 37 nM. | |||||||||||||||||||||
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References
- [1]. Justine T Tigno-Aranjuez, et al. In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. J Biol Chem. 2014 Oct 24;289(43):29651-64. [Content Brief]
- [2]. Gonzalo Sánchez-Duffhues, et al. Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva-Derived Endothelial Cells. JBMR Plus. 2019 Oct 7;3(11):e10230. [Content Brief]
Keywords
