239480-61-6
Chemical Structure
NBI-6024
- CAS No.: 239480-61-6
- Formula:C106H180N28O34
- Molecular Weight:2390.73
InChIKey: VGGRNGOEDNBLPH-YJHCMWSWSA-N
SMILES: O=C([C@@H](N)C(C)C)N[C@H](C(NCC(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(O)=O)=O)CCC(O)=O)=O)CC(N)=O)=O)C)=O)CCC2)=O)[C@@H](C)O)=O)CC(C)C)=O)CO)=O)CC(O)=O)=O)CC(C)C)=O)C)=O)CCC1)=O)[C@H](CC)C)=O)C(C)C)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(C)C)=O)C)=O)C(C)C)=O)=O)=O)=O)CC(C)C
Biological Activity: NBI-6024, an altered peptide ligand (APL), is an epitope recognized by inflammatory interferon-gamma-producing T helper lymphocytes in type 1 diabetic patients[1][2].
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NBI-6024 | NBI-6024, an altered peptide ligand (APL), is an epitope recognized by inflammatory interferon-gamma-producing T helper lymphocytes in type 1 diabetic patients. | |||||||||||||||||||||
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- [1]. D G Alleva et al. Immunomodulation in type 1 diabetes by NBI-6024, an altered peptide ligand of the insulin B epitope. Scand J Immunol. 2006 Jan;63(1):59-69. [Content Brief]
- [2]. Alleva DG, et al. Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide. Diabetes. 2002 Jul;51(7):2126-34. [Content Brief]
Keywords
