2403598-42-3
Chemical Structure
HPK1-IN-18
- CAS No.: 2403598-42-3
- Formula:C24H24N4
- Molecular Weight:368.47
IUPAC Name: 5-(4-(4-methylpiperazin-1-yl)phenyl)-3-phenyl-1H-pyrrolo[2,3-b]pyridine
InChIKey: AWUUNVCRTLNKKY-UHFFFAOYSA-N
SMILES: CN(CC1)CCN1C2=CC=C(C=C2)C3=CN=C(NC=C4C5=CC=CC=C5)C4=C3
Biological Activity: HPK1-IN-18 is a potent and selective inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPKl) originally cloned from hematopoietic progenitor cells is a member of MAP kinase kinase kinase kinases (MAP4Ks) family. HPK1-IN-18 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer (extracted from patent WO2019238067A1, compound 1)[1].
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HPK1-IN-18 | HPK1-IN-18 is a potent and selective inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPKl) originally cloned from hematopoietic progenitor cells is a member of MAP kinase kinase kinase kinases (MAP4Ks) family. HPK1-IN-18 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer (extracted from patent WO2019238067A1, compound 1). | |||||||||||||||||||||
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Keywords
