240423-23-8
240423-23-8
Chemical Structure
Salvicine
- CAS No.: 240423-23-8
- Formula:C20H26O4
- Molecular Weight:330.42
InChIKey: NZIUPDOWWMGNCV-UHFFFAOYSA-N
SMILES: O=C1C(C(C(C)C)=CC2=C1C(CCC(C(C)(C)O)O)=C(C)C=C2)=O
Biological Activity: Salvicine is a DNA topoisomerase II inhibitor (IC50=3 μM). Salvicine increases the interaction between DNA and Topo II by interacting with the ATPase domain, inhibiting DNA degradation and ATP hydrolysis. Salvicine has anticancer activities, including inhibiting Topo II, causing DNA damage, overcoming multidrug resistance, and inhibiting tumor cell adhesion[1][2].
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Salvicine | Salvicine is a DNA topoisomerase II inhibitor (IC50=3 μM). Salvicine increases the interaction between DNA and Topo II by interacting with the ATPase domain, inhibiting DNA degradation and ATP hydrolysis. Salvicine has anticancer activities, including inhibiting Topo II, causing DNA damage, overcoming multidrug resistance, and inhibiting tumor cell adhesion. | |||||||||||||||||||||
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References
- [1]. Dey D, et al. Investigating the anticancer potential of salvicine as a modulator of topoisomerase II and ROS signaling cascade[J]. Frontiers in oncology, 2022, 12: 899009. [Content Brief]
- [2]. Meng L, et al. Salvicine, a novel DNA topoisomerase II inhibitor, exerting its effects by trapping enzyme-DNA cleavage complexes[J]. Biochemical pharmacology, 2001, 62(6): 733-741. [Content Brief]
Keywords
