2407861-48-5
Chemical Structure
Anticancer agent 65
- CAS No.: 2407861-48-5
- Formula:C36H63NO5
- Molecular Weight:589.89
IUPAC Name: (3S,5R,8R,9R,10R,12R,13R,14R,17S)-17-((R)-2,6-dihydroxy-6-methylheptan-2-yl)-12-hydroxy-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl piperidine-4-carboxylate
InChIKey: AFACQRIUMCYKAU-QZBQRUMZSA-N
SMILES: C[C@]12[C@]3([C@@]([C@@H](C[C@]1([H])[C@@]4([C@@](C(C)([C@H](CC4)OC(C5CCNCC5)=O)C)([H])CC2)C)O)([H])[C@@](CC3)([H])[C@](C)(O)CCCC(C)(O)C)C
Biological Activity: Anticancer agent 65 (compound 4c) shows excellent activity in cancer cell lines, especially A549 cells, with an IC50 of 1.07 μM. Anticancer agent 65 induces S-phase arrest in A549 cells and increases the expression level of p53 and p21. Anticancer agent 65 causes apoptosis, ROS generation and collapse of MMP in A549 cells[1].
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Anticancer agent 65 | Anticancer agent 65 (compound 4c) shows excellent activity in cancer cell lines, especially A549 cells, with an IC50 of 1.07 μM. Anticancer agent 65 induces S-phase arrest in A549 cells and increases the expression level of p53 and p21. Anticancer agent 65 causes apoptosis, ROS generation and collapse of MMP in A549 cells. | |||||||||||||||||||||
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Keywords
