2408913-88-0
Chemical Structure
PTO-41
- CAS No.: 2408913-88-0
- Formula:C27H30BF2NO3
- Molecular Weight:465.34
InChIKey: XIQJCVLOKIPXJN-YDFGWWAZSA-N
SMILES: CCC1=CC=C(C=C1)C2=C(O[B-](F)([O+]=C2C3CC3)F)/C=C/C=C/C4=CC=C(C=C4)N(CCO)C
Biological Activity: PTO-41 is a blood-brain barrier-permeable near-infrared fluorescent probe that targets β-amyloid oligomers (Aβ Oligomers, AβOs) with a Kd of 349 nM. PTO-41 exhibits low cytotoxicity, high sensitivity to β-amyloid oligomers in in vitro phantom imaging, and can be rapidly cleared from the brain. PTO-41 is applicable to the research of Alzheimer's disease (Ex/Em = 538 nM/680 nM)[1].
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PTO-41 | PTO-41 is a blood-brain barrier-permeable near-infrared fluorescent probe that targets β-amyloid oligomers (Aβ Oligomers, AβOs) with a Kd of 349 nM. PTO-41 exhibits low cytotoxicity, high sensitivity to β-amyloid oligomers in in vitro phantom imaging, and can be rapidly cleared from the brain. PTO-41 is applicable to the research of Alzheimer's disease (Ex/Em = 538 nM/680 nM). | |||||||||||||||||||||
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Keywords
