2408993-39-3
Chemical Structure
Fmoc-L-Lys(N3-Aca-DIM)-OH
- CAS No.: 2408993-39-3
- Formula:C35H43N5O6
- Molecular Weight:629.75
IUPAC Name: N2-(((9H-fluoren-9-yl)methoxy)carbonyl)-N6-(6-azido-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)hexyl)-L-lysine
InChIKey: UKGXBOFMFOMLNU-LJAQVGFWSA-N
SMILES: [N-]=[N+]=NCCCCC/C(NCCCC[C@@H](C(O)=O)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)=C4C(CC(C)(CC/4=O)C)=O
Biological Activity: Fmoc-L-Lys(N3-Aca-DIM)-OH is a click chemistry reagent containing an azide group. Used as a SPPS building-block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilizing residues are attached to the Lys side-chains using Click-chemistry. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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Fmoc-L-Lys(N3-Aca-DIM)-OH | Fmoc-L-Lys(N3-Aca-DIM)-OH is a click chemistry reagent containing an azide group. Used as a SPPS building-block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilizing residues are attached to the Lys side-chains using Click-chemistry. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. | |||||||||||||||||||||
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