2410789-80-7
2410789-80-7
Chemical Structure
EGFR-IN-218
- CAS No.: 2410789-80-7
- Formula:C34H39FN8O2
- Molecular Weight:610.72
InChIKey: KTZRJJUCNLXSMT-UHFFFAOYSA-N
SMILES: FC(C=C1)=CC=C1C2=NC=CN2C3=CC(NC4=C(OC)C=C(N5CCC(N6CCN(C)CC6)CC5)C(NC(C=C)=O)=C4)=NC=C3
Biological Activity: EGFR-IN-218 is an orally effective EGFR inhibitor with IC50 values of 3.85, 0.40, and 140.5 nM against EGFRWT, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively. EGFR-IN-218 inhibits EGFR phosphorylation and downstream ERK1/2 signaling, and exhibits in vivo antitumor activity. EGFR-IN-218 can be used for research on EGFR-mutant non-small cell lung cancer, glioblastoma, and brain metastasis[1].
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EGFR-IN-218 | EGFR-IN-218 is an orally effective EGFR inhibitor with IC50 values of 3.85, 0.40, and 140.5 nM against EGFRWT, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively. EGFR-IN-218 inhibits EGFR phosphorylation and downstream ERK1/2 signaling, and exhibits in vivo antitumor activity. EGFR-IN-218 can be used for research on EGFR-mutant non-small cell lung cancer, glioblastoma, and brain metastasis. | |||||||||||||||||||||
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