241151-12-2
Chemical Structure
Ro-65-2299
- CAS No.: 241151-12-2
- Formula:C21H30F6O3
- Molecular Weight:444.45
IUPAC Name: (1R,3R)-5-((2E,9Z)-12,12,12-trifluoro-11-hydroxy-7,7-dimethyl-11-(trifluoromethyl)dodeca-2,9-dien-1-ylidene)cyclohexane-1,3-diol
InChIKey: PKGBMNJPRJDFJA-KROAHAAKSA-N
SMILES: O[C@H]1C[C@H](O)C/C(C1)=C/C=C/CCCC(C)(C)C/C=C\C(C(F)(F)F)(O)C(F)(F)F
Biological Activity: Ro-65-2299 is an orally active retiferol Vitamin D analogue and a potential VDR agonist (ED50 = 180 nM). Ro-65-2299 can induce thickening of the epidermis and exhibits antipsoriatic effect in hairless mice (ED50 = 7.5 mg/kg). Ro-65-2299 can be used for the researches of inflammation and immunology, such as psoriasis[1].
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Ro-65-2299 | Ro-65-2299 is an orally active retiferol Vitamin D analogue and a potential VDR agonist (ED50 = 180 nM). Ro-65-2299 can induce thickening of the epidermis and exhibits antipsoriatic effect in hairless mice (ED50 = 7.5 mg/kg). Ro-65-2299 can be used for the researches of inflammation and immunology, such as psoriasis. | |||||||||||||||||||||
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Keywords
