2414607-10-4
Chemical Structure
SKLB0565
- CAS No.: 2414607-10-4
- Formula:C20H25ClN6O
- Molecular Weight:400.91
IUPAC Name: 3-(((2-chloro-9-cyclopentyl-9H-purin-6-yl)amino)methyl)-4,6-diethylpyridin-2(1H)-one
InChIKey: CQTZFKRSEFNMLM-UHFFFAOYSA-N
SMILES: O=C1C(CNC2=C3N=CN(C4CCCC4)C3=NC(Cl)=N2)=C(CC)C=C(CC)N1
Biological Activity: SKLB0565 is a potent tubulin inhibitor. SKLB0565 shows significant anti-proliferative activity against CRC (colorectal carcinoma) cell lines, with IC50 values ranging from 0.012 μM to 0.081 μM. SKLB0565 causes G2/M phase arrest and mitochondria-mediated intrinsic apoptosis. SKLB0565 inhibits cell migration and disrupted the tube formation of HUVECs[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
SKLB0565 | SKLB0565 is a potent tubulin inhibitor. SKLB0565 shows significant anti-proliferative activity against CRC (colorectal carcinoma) cell lines, with IC50 values ranging from 0.012 μM to 0.081 μM. SKLB0565 causes G2/M phase arrest and mitochondria-mediated intrinsic apoptosis. SKLB0565 inhibits cell migration and disrupted the tube formation of HUVECs. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
