2414607-10-4
2414607-10-4
Chemical Structure
SKLB0565
- CAS No.: 2414607-10-4
- Formula:C20H25ClN6O
- Molecular Weight:400.91
IUPAC Name: 3-(((2-chloro-9-cyclopentyl-9H-purin-6-yl)amino)methyl)-4,6-diethylpyridin-2(1H)-one
InChIKey: CQTZFKRSEFNMLM-UHFFFAOYSA-N
SMILES: O=C1C(CNC2=C3N=CN(C4CCCC4)C3=NC(Cl)=N2)=C(CC)C=C(CC)N1
Biological Activity: SKLB0565 is a potent tubulin inhibitor. SKLB0565 shows significant anti-proliferative activity against CRC (colorectal carcinoma) cell lines, with IC50 values ranging from 0.012 μM to 0.081 μM. SKLB0565 causes G2/M phase arrest and mitochondria-mediated intrinsic apoptosis. SKLB0565 inhibits cell migration and disrupted the tube formation of HUVECs[1].
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SKLB0565 | SKLB0565 is a potent tubulin inhibitor. SKLB0565 shows significant anti-proliferative activity against CRC (colorectal carcinoma) cell lines, with IC50 values ranging from 0.012 μM to 0.081 μM. SKLB0565 causes G2/M phase arrest and mitochondria-mediated intrinsic apoptosis. SKLB0565 inhibits cell migration and disrupted the tube formation of HUVECs. | |||||||||||||||||||||
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