2415374-98-8
Chemical Structure
GNE-6893
- CAS. Nr.: 2415374-98-8
- Formula:C23H24FN5O4
- Molecular Weight:453.47
IUPAC Name: (3R,4S)-4-methyltetrahydrofuran-3-yl (8-amino-7-fluoro-6-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)isoquinolin-3-yl)carbamate
InChIKey: ABFKLHVMHUGOBS-GTNSWQLSSA-N
SMILES: FC1=C(N)C(C=NC(NC(O[C@@H]2[C@H](COC2)C)=O)=C3)=C3C=C1C4=CN=C(OCCN5)C5=C4C
Biological Activity: GNE-6893 is an orally active, selective HPK1 inhibitor with a Ki < 0.02 nM. GNE-6893 enhances T cell receptor signaling in primary human T cells. GNE-6893 increases IL2 production in stimulated primary human T cells. GNE-6893 can be used for the research of chronic refractory cancers[1].
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GNE-6893 | 99.94% | GNE-6893 is an orally active, selective HPK1 inhibitor with a Ki < 0.02 nM. GNE-6893 enhances T cell receptor signaling in primary human T cells. GNE-6893 increases IL2 production in stimulated primary human T cells. GNE-6893 can be used for the research of chronic refractory cancers. | ||||||||||||||||||||
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