2415715-84-1
Chemical Structure
Fosigotifator
Synonym(s): ABBV-CLS-7262
- CAS No.: 2415715-84-1
- Formula:C25H27Cl2F2N2O9P
- Molecular Weight:639.37
IUPAC Name: (S)-((1,4-bis(2-(4-chloro-3-fluorophenoxy)acetamido)bicyclo[2.2.2]octan-2-yl)oxy)methyl dihydrogen phosphate
InChIKey: IURMHIZNAHLQRX-ANYOXOOPSA-N
SMILES: O=C(COC(C=C1)=CC(F)=C1Cl)NC(CCC23NC(COC(C=C4)=CC(F)=C4Cl)=O)(CC2)[C@H](C3)OCO[P](O)(O)=O
Biological Activity: Fosigotifator (ABBV-CLS-7262) is a brain penetrant, orally active EIF2b (eukaryotic initiation factor) activator. Fosigotifator stabilizes the elF2B complex and boosts the activity, including that of complexes carrying pathogenic vanishing white matter (VWM) mutations. Fosigotifator is an integrated stress response inhibitor (ISRI). Fosigotifator can be used for amyotrophic lateral sclerosis research[1][2].
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Fosigotifator | Fosigotifator (ABBV-CLS-7262) is a brain penetrant, orally active EIF2b (eukaryotic initiation factor) activator. Fosigotifator stabilizes the elF2B complex and boosts the activity, including that of complexes carrying pathogenic vanishing white matter (VWM) mutations. Fosigotifator is an integrated stress response inhibitor (ISRI). Fosigotifator can be used for amyotrophic lateral sclerosis research. | |||||||||||||||||||||
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- [1]. Michael Hayden, et al. Method of treating amyotrophic lateral sclerosis with pridopidine. US20230190724 A1. 2023.6.22.
- [2]. Amos Baruch, et al. Development of eIF2B Activator ABBV-CLS-7262 as a Novel Treatment for Vanishing White Matter Disease (P2-8.001). Neurology. Volume 102 Number 7 April 09,2024
Keywords
