2419180-34-8
Chemical Structure
WEN05-03
- CAS No.: 2419180-34-8
- Formula:C17H14N4O4S
- Molecular Weight:370.38
IUPAC Name: 2-((2-amino-2-oxoethyl)thio)-N-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-6-yl)benzamide
InChIKey: WFFCWUWLJVDMNN-UHFFFAOYSA-N
SMILES: O=C(N)CSC=1C=CC=CC1C(=O)NC2=CC=C3NC(=O)C(=O)NC3=C2
Biological Activity: WEN05-03 is a EscN ATPase inhibitor. WEN05-03 blocks the active site of EscN ATPase and competitively inhibits its ATP hydrolysis activity. WEN05-03 completely blocks actin cluster formation, reduces actin pedestal formation, and decreases the toxicity of infected mammalian cells. WEN05-03 can be used in studies related to enteropathogenic E. coli (EPEC) infection[1][2].
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WEN05-03 | WEN05-03 is a EscN ATPase inhibitor. WEN05-03 blocks the active site of EscN ATPase and competitively inhibits its ATP hydrolysis activity. WEN05-03 completely blocks actin cluster formation, reduces actin pedestal formation, and decreases the toxicity of infected mammalian cells. WEN05-03 can be used in studies related to enteropathogenic E. coli (EPEC) infection. | |||||||||||||||||||||
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- [1]. Bzdzion L, et al. Design of small molecule inhibitors of type III secretion system ATPase EscN from enteropathogenic Escherichia coli. Acta Biochim Pol. 2017;64(1):49-63. [Content Brief]
- [2]. Fasciano AC, et al. Promises and Challenges of the Type Three Secretion System Injectisome as an Antivirulence Target. EcoSal Plus. 2019 Feb;8(2):10.1128/ecosalplus.ESP-0032-2018. [Content Brief]
Keywords
