2419580-01-9
Chemical Structure
E8431
- CAS No.: 2419580-01-9
- Formula:C24H26N2O3
- Molecular Weight:390.47
InChIKey: POWUNRWKQYKBBA-UHFFFAOYSA-N
SMILES: O=C1C2=CC(NC(N3CC4(C5=CC=CC=C5CC4)OCC3)=O)=CC=C2CCCC1
Biological Activity:
E8431 is a DCSTAMP antagonist. DCSTAMP is a key fusion protein that coordinates cell-cell fusion during osteoclastogenesis. E8431 inhibits the cytoskeleton reorganization mediated by the RAP1B-RAC1 signaling pathway. E8431 has the ability to inhibit pre-fusion of osteoclasts and, while inhibiting bone resorption, stimulates the secretion of PDGFBB, thereby stimulating the process of bone and blood vessel formation. E8431 effectively reduces bone loss in a mouse model caused by ovariectomy. E8431 can be used for the study of osteoporosis[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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E8431 | 97.34% | E8431 is a DCSTAMP antagonist. DCSTAMP is a key fusion protein that coordinates cell-cell fusion during osteoclastogenesis. E8431 inhibits the cytoskeleton reorganization mediated by the RAP1B-RAC1 signaling pathway. E8431 has the ability to inhibit pre-fusion of osteoclasts and, while inhibiting bone resorption, stimulates the secretion of PDGFBB, thereby stimulating the process of bone and blood vessel formation. E8431 effectively reduces bone loss in a mouse model caused by ovariectomy. E8431 can be used for the study of osteoporosis. |
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Keywords
