2422019-91-6
Chemical Structure
Antifungal agent 30
- CAS No.: 2422019-91-6
- Formula:C18H14Cl2F2N2Se
- Molecular Weight:446.18
IUPAC Name: 1-(2-((2,4-dichlorobenzyl)selanyl)-2-(2,4-difluorophenyl)ethyl)-1H-imidazole
InChIKey: GRJWDMJBIUKXIM-UHFFFAOYSA-N
SMILES: FC1=CC(F)=C(C=C1)C([Se]CC2=C(C=C(C=C2)Cl)Cl)CN3C=CN=C3
Biological Activity: Antifungal agent 30 (compound A18) is a potent antifungal agent. Antifungal agent 30 shows excellent antifungal activity against Candida albicans (CPCC400616) and Aspergillus fumigatus, with MIC of 0.03 and 0.5 μg/mL, respectively. Antifungal agent 30 also shows excellent antifungal activity against fluconazole-resistant strains. The potent antifungal activity of Antifungal agent 30 mainly causes by hydrogen and coordination bond interaction with the CYP51[1].
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Antifungal agent 30 | Antifungal agent 30 (compound A18) is a potent antifungal agent. Antifungal agent 30 shows excellent antifungal activity against Candida albicans (CPCC400616) and Aspergillus fumigatus, with MIC of 0.03 and 0.5 μg/mL, respectively. Antifungal agent 30 also shows excellent antifungal activity against fluconazole-resistant strains. The potent antifungal activity of Antifungal agent 30 mainly causes by hydrogen and coordination bond interaction with the CYP51. | |||||||||||||||||||||
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