2422053-29-8
Chemical Structure
Debio 1453
- CAS No.: 2422053-29-8
- Formula:C23H24N4O4
- Molecular Weight:420.46
InChIKey: YEFHSSWFLULRED-UGZSOSCUSA-N
SMILES: CC1=C(OC2=C1C=CC=C2)CN(C(/C=C/C3=CN=C4NC([C@H]([C@H](NC4=C3)C)O)=O)=O)C
Biological Activity: Debio 1453 is a bactericidal FabI inhibitor potent against N. gonorrhoeae (IC50 = 0.6 nM), including drug-resistant strains. Debio 1453 demonstrates a low propensity for resistance selection and is effective in eradicating both planktonic and intracellular bacteria through a mechanism of concurrently inhibiting FabI and engaging the non-mutable NADH cofactor. Debio 1453 clears antibiotic-resistant N. gonorrhoeae infection in a murine vaginal model. Debio 1453 can be used for gonorrhoea research[1].
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Debio 1453 | Debio 1453 is a bactericidal FabI inhibitor potent against N. gonorrhoeae (IC50 = 0.6 nM), including drug-resistant strains. Debio 1453 demonstrates a low propensity for resistance selection and is effective in eradicating both planktonic and intracellular bacteria through a mechanism of concurrently inhibiting FabI and engaging the non-mutable NADH cofactor. Debio 1453 clears antibiotic-resistant N. gonorrhoeae infection in a murine vaginal model. Debio 1453 can be used for gonorrhoea research. | |||||||||||||||||||||
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