2451219-73-9
Chemical Structure
BRD4 Inhibitor-18
- CAS No.: 2451219-73-9
- Formula:C26H26ClN3O3S
- Molecular Weight:496.02
IUPAC Name: 2-(6-(4-chlorophenyl)-8-methoxy-1-methyl-2-oxo-1,4-dihydro-2H-benzo[c]thiazolo[4,5-e]azepin-4-yl)-N-cyclopentylacetamide
InChIKey: YNWSIAIOTZOOBK-UHFFFAOYSA-N
SMILES: COC1=CC2=C(C=C1)C3=C(SC(N3C)=O)C(CC(NC4CCCC4)=O)N=C2C5=CC=C(Cl)C=C5
Biological Activity: BRD4 Inhibitor-18 is a highly potent BRD4 inhibitor with an IC50 value of 110 nM. BRD4 Inhibitor-18 has a hydrophobic acetylcyclopentanyl side chain. BRD4 Inhibitor-18 can significantly suppress the proliferation of MV-4-11 cells with high BRD4 level. BRD4 Inhibitor-18 has apoptosis-promoting and G0/G1 cycle-arresting activity[1].
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BRD4 Inhibitor-18 | BRD4 Inhibitor-18 is a highly potent BRD4 inhibitor with an IC50 value of 110 nM. BRD4 Inhibitor-18 has a hydrophobic acetylcyclopentanyl side chain. BRD4 Inhibitor-18 can significantly suppress the proliferation of MV-4-11 cells with high BRD4 level. BRD4 Inhibitor-18 has apoptosis-promoting and G0/G1 cycle-arresting activity. | |||||||||||||||||||||
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Keywords
