BRD4 Inhibitor-18
BRD4 Inhibitor-18 is a highly potent BRD4 inhibitor with an IC50 value of 110 nM. BRD4 Inhibitor-18 has a hydrophobic acetylcyclopentanyl side chain. BRD4 Inhibitor-18 can significantly suppress the proliferation of MV-4-11 cells with high BRD4 level. BRD4 Inhibitor-18 has apoptosis-promoting and G0/G1 cycle-arresting activity.
For research use only. We do not sell to patients.
- CAS No.: 2451219-73-9
- Formula: C26H26ClN3O3S
- Molecular Weight:496.02
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
BRD4 110 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
5.52 μM
Compound: 13f
|
Antiproliferative activity against human HL60 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HL60 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
|
[PMID: 32631570] |
| MV4-11 | IC50 |
0.42 μM
Compound: 13f
|
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
|
[PMID: 32631570] |
BRD4 Inhibitor-18 (compound 13f) (0-10 μM; 72 hours) can suppress the proliferation of HL-60 and MV-41 cells[1].
BRD4 Inhibitor-18 (0.5 and 5 μM; 12 hours) significantly arrests MV-4-11 cells in G1 phase in a dose-dependent manner[1].
BRD4 Inhibitor-18 (0.5 and 5 μM; 12 hours) effectively induces apoptosis of MV-4-11 cells in a dose-dependent manner[1].
BRD4 Inhibitor-18 (0.5 and 5 μM; 4 hours) inhibits the expression of c-Myc protein in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HL-60 and MV-4-11[1]
-
Concentration:0-10 μM
-
Incubation Time:72 hours
-
Result:Suppressed the proliferation of HL-60 and MV-41 cells with IC50s of 5.52 μM and 0.42 μM.
-
Cell Line:MV-4-11 cells[1]
-
Concentration:0.5 and 5 μM
-
Incubation Time:12 hours
-
Result:Significantly arrested MV-4-11 cells in G1 phase, with the G0/G1 cell proportions of 50.87% and 70.66% at 0.5 and 5 μM.
-
Cell Line:MV-4-11 cells[1]
-
Concentration:0.5 and 5 μM
-
Incubation Time:12 hours
-
Result:Effectively induced apoptosis of MV-4-11 cells, with apoptosis rates of 12.39% and 73.24% at at 0.5 and 5 μM.
-
Cell Line:MV-4-11 cells[1]
-
Concentration:0.5 and 5 μM
-
Incubation Time:4 hours
-
Result:Inhibited the expression of c-Myc protein in a dose-dependent manner.
Chemical Information
-
CAS No. 2451219-73-9
-
Molecular Weight 496.02
-
Formula C26H26ClN3O3S
-
SMILES
COC1=CC2=C(C=C1)C3=C(SC(N3C)=O)C(CC(NC4CCCC4)=O)N=C2C5=CC=C(Cl)C=C5
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BRD4 Inhibitor-18 Related Classifications
HY-146660 Related Classifications
Powered by Bioz