2459707-59-4
2459707-59-4
Chemical Structure
HIV-1-IN-88
- CAS No.: 2459707-59-4
- Formula:C32H44N4O10S
- Molecular Weight:676.78
InChIKey: KWFXPFULNOYBHH-KKRKHOSVSA-N
SMILES: O[C@@H]([C@@H](NC([C@H](CC(N)=O)NC(O[C@@]1([C@]2([C@@]([H])(OC1)OCC2)[H])[H])=O)=O)CC3=CC=CC=C3)CN(CC(C)C)S(=O)(C4=CC=C(C=C4)OC)=O
Biological Activity: HIV-1-IN-88 (compound 20a) is a potent HIV‑1 protease inhibitor (IC50 = 10 pM) with an antiviral EC50 of 10.4 nM. HIV-1-IN-88 exhibits potency against the multidrug-resistant variants HIV-1Muta and HIV-1I50V with EC50 values of 30.0 and 34.3 nM, respectively. HIV-1-IN-88 can be used for HIV research[1].
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HIV-1-IN-88 | HIV-1-IN-88 (compound 20a) is a potent HIV‑1 protease inhibitor (IC50 = 10 pM) with an antiviral EC50 of 10.4 nM. HIV-1-IN-88 exhibits potency against the multidrug-resistant variants HIV-1Muta and HIV-1I50V with EC50 values of 30.0 and 34.3 nM, respectively. HIV-1-IN-88 can be used for HIV research. | |||||||||||||||||||||
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References
Keywords
