2568276-37-7
2568276-37-7
Chemical Structure
PROTAC SMARCA2 degrader-16
- CAS No.: 2568276-37-7
- Formula:C41H47N11O4
- Molecular Weight:757.88
InChIKey: WCOIOTJAJUOTNM-UHFFFAOYSA-N
SMILES: OC1=CC=CC=C1C2=CC(N3CC4CCC(N4C5=NC(C6CCN(CCCC7=CC(N(C)C(N8C9CCC(NC9=O)=O)=O)=C8C=C7)CC6)=NC=C5)C3)=C(N)N=N2
Biological Activity: PROTAC SMARCA2 degrader-16 (compound I-278) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment[1].
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PROTAC SMARCA2 degrader-16 | PROTAC SMARCA2 degrader-16 (compound I-278) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment. | |||||||||||||||||||||
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References
Keywords
