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Art. -Nr.: HY-162742

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PROTAC SMARCA2 degrader-16

PROTAC SMARCA2 degrader-16 (compound I-278) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment.
(Pink: ligand (HY-163926); Blue: Cereblon ligand (HY-163927); Black: linker).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2568276-37-7
Formel: C₄₁H₄₇N₁₁O₄
Molecular Weight:757.88

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PROTAC SMARCA2 degrader-16 Chemical Structure

CAS. Nr.: 2568276-37-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

PROTAC SMARCA2 degrader-16 (compound I-278) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment^[1]. (Pink: ligand (HY-163926); Blue: Cereblon ligand (HY-163927); Black: linker).

IC₅₀ & Target

SMARCA2^[1]

Alle PROTACs Isoform-spezifische Produkte anzeigen :

In Vitro

PROTAC SMARCA2 degrader-16 (24 h) induces potent SMARCA2 protein degradation in A549 cells with a DC₅₀ <100 nM and >90% maximum degradation after 24 hours^[1].
PROTAC SMARCA2 degrader-16 (24 h) induces potent SMARCA4 protein degradation in MV4-11 cells with a DC₅₀ <100 nM and >90% maximum degradation after 24 hours^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2568276-37-7
Molecular Weight 757.88
Formel C₄₁H₄₇N₁₁O₄
SMILES

OC1=CC=CC=C1C2=CC(N3CC4CCC(N4C5=NC(C6CCN(CCCC7=CC(N(C)C(N8C9CCC(NC9=O)=O)=O)=C8C=C7)CC6)=NC=C5)C3)=C(N)N=N2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Preparation of heterocyclic compounds as SMARCA degraders and uses thereof. World Intellectual Property Organization, WO2020251971 A1 2020-12-17.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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