2582816-37-1
Chemical Structure
XT2
- CAS No.: 2582816-37-1
- Formula:C19H14FN5OS
- Molecular Weight:379.41
IUPAC Name: (R)-4-(3-(2-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-fluorophenyl)-2-(thiazol-2-yl)but-3-yn-2-ol
InChIKey: NFAPIBSJICIXGB-LJQANCHMSA-N
SMILES: FC1=CC=C(C#C[C@@](O)(C2=NC=CS2)C)C=C1C(C3=N4)=CNC3=CN=C4N
Biological Activity: XT2 is a potent, orally active, and selective inhibitor of NF-κB-inducing kinase (NIK) with an IC50 of 9.1 nM. XT2 suppresses CCl4-induced upregulation of ALT, a key biomarker of acute liver injury. XT2 also decreases immune cell infiltration into the injured liver tissue. XT2 has the potential for the research of liver inflammatory diseases[1]. XT2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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XT2 | 99.60% | XT2 is a potent, orally active, and selective inhibitor of NF-κB-inducing kinase (NIK) with an IC50 of 9.1 nM. XT2 suppresses CCl4-induced upregulation of ALT, a key biomarker of acute liver injury. XT2 also decreases immune cell infiltration into the injured liver tissue. XT2 has the potential for the research of liver inflammatory diseases. XT2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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Keywords
