2585561-49-3
Chemical Structure
PROTAC BRD4 Degrader-17
- CAS No.: 2585561-49-3
- Formula:C49H47N7O9
- Molecular Weight:877.94
IUPAC Name: 1-(3-methoxybenzyl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[3,2-c]quinolin-4-amine
InChIKey: HBAAAVQUHXUWNR-UHFFFAOYSA-N
SMILES: CN1C=C(C2=C(C1=O)NC(C(NCC3=CC=C(C=C3)C(NCCCCNC4=C5C(N(C(C5=CC=C4)=O)C6CCC(NC6=O)=O)=O)=O)=O)=C2)C7=CC(C(C)(C)O)=CC=C7OC8=CC=CC=C8
Biological Activity: PROTAC BRD4 Degrader-17 (compound 13i) is a potent PROTAC BRD4 Degrader, with IC50 values of 29.54 nM (BRD4 (BD1)) and 3.82 nM (BRD4 (BD2)). PROTAC BRD4 Degrader-17 significantly attenuates G2/M progression associated Cyclin B1 expression. PROTAC BRD4 Degrader-17 significantly induces apoptosis in MV-4-11 cells[1].
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PROTAC BRD4 Degrader-17 | PROTAC BRD4 Degrader-17 (compound 13i) is a potent PROTAC BRD4 Degrader, with IC50 values of 29.54 nM (BRD4 (BD1)) and 3.82 nM (BRD4 (BD2)). PROTAC BRD4 Degrader-17 significantly attenuates G2/M progression associated Cyclin B1 expression. PROTAC BRD4 Degrader-17 significantly induces apoptosis in MV-4-11 cells. | |||||||||||||||||||||
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