2596358-28-8
2596358-28-8
Chemical Structure
FFN511 hydrochloride
- CAS No.: 2596358-28-8
- Formula:C17H21ClN2O2
- Molecular Weight:320.81
InChIKey: HHRZEPOCKPCJSA-UHFFFAOYSA-N
SMILES: O=C1OC2=C(C(CCN)=C1)C=C3C4=C2CCCN4CCC3.Cl
Biological Activity: FFN511 (hydrochloride) is a potent fluorescent false neurotransmitters (FFNs) that targets neuronal vesicular monoamine transporter 2 (VMA T2). FFN511 (hydrochloride) inhibits serotonin binding to VMA T2-containing membranes with an IC50 of 1 µM. FFN511 (hydrochloride) directly images the dynamics of release during exocytosis, can be used to label dopamine terminals in live cortical-striatalacute slices[1][2].
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FFN511 hydrochloride | FFN511 (hydrochloride) is a potent fluorescent false neurotransmitters (FFNs) that targets neuronal vesicular monoamine transporter 2 (VMA T2). FFN511 (hydrochloride) inhibits serotonin binding to VMA T2-containing membranes with an IC50 of 1 µM. FFN511 (hydrochloride) directly images the dynamics of release during exocytosis, can be used to label dopamine terminals in live cortical-striatalacute slices. | |||||||||||||||||||||
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References
- [1]. Gubernator NG, et al. Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals. Science. 2009 Jun 12;324(5933):1441-4. [Content Brief]
- [2]. Keighron JD, et al. Analytical tools to monitor exocytosis: a focus on new fluorescent probes and methods. Analyst. 2012 Apr 21;137(8):1755-63. [Content Brief]
