2597167-34-3
Chemical Structure
PROTAC Chk1 degrader-1
- CAS No.: 2597167-34-3
- Formula:C43H44N14O9
- Molecular Weight:900.90
InChIKey: HUEILOSTKICPMD-UHFFFAOYSA-N
SMILES: N#CCC1=CC=C(NC2=NC(C(NCC3=CN(CCOCCOCCNC(COC4=C5C(C(N(C6C(NC(CC6)=O)=O)C5=O)=O)=CC=C4)=O)N=N3)=O)=CC(NC7=NNC(C8CC8)=C7)=N2)C=C1
Biological Activity: PROTAC Chk1 degrader-1 is a Chk1-targeting PROTAC.PROTAC Chk1 degrader-1 recruits the Cereblon E3 ligase to induce ubiquitination and proteasomal degradation of Chk1.PROTAC Chk1 degrader-1 exhibits Chk1 degradation activity in malignant melanoma cells without showing a hook effect.PROTAC Chk1 degrader-1 can be used for the research of malignant melanoma[1].
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PROTAC Chk1 degrader-1 | 99.70% | PROTAC Chk1 degrader-1 is a Chk1-targeting PROTAC.PROTAC Chk1 degrader-1 recruits the Cereblon E3 ligase to induce ubiquitination and proteasomal degradation of Chk1.PROTAC Chk1 degrader-1 exhibits Chk1 degradation activity in malignant melanoma cells without showing a hook effect.PROTAC Chk1 degrader-1 can be used for the research of malignant melanoma. | ||||||||||||||||||||
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Keywords
