259728-61-5
259728-61-5
Chemical Structure
Funalenone
Synonym(s): BMS-304245
- CAS No.: 259728-61-5
- Formula:C15H12O6
- Molecular Weight:288.25
IUPAC Name: 3,4,7,9-tetrahydroxy-2-methoxy-6-methyl-1H-phenalen-1-one
InChIKey: QAPJKCNKHLDDAK-UHFFFAOYSA-N
SMILES: O=C1C(OC)=C(O)C2=C3C1=C(O)C=C(O)C3=C(C)C=C2O
Biological Activity: Funalenone (BMS-304245) is a MraY + MurG inhibitor with an IC50 of 25.5 μM in a MraY + MurG membrane plate assay. Funalenone inhibits Staphylococcus aureus (A15090) with an MIC of 64 μg/mL. Funalenone also inhibits MMP-1 with an IC50 of 170 μM[1][2].
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Funalenone | Funalenone (BMS-304245) is a MraY + MurG inhibitor with an IC50 of 25.5 μM in a MraY + MurG membrane plate assay. Funalenone inhibits Staphylococcus aureus (A15090) with an MIC of 64 μg/mL. Funalenone also inhibits MMP-1 with an IC50 of 170 μM. | |||||||||||||||||||||
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References
- [1]. J Inokoshi, et al. Funalenone, a novel collagenase inhibitor produced by Aspergillus niger. J Antibiot (Tokyo). 1999 Dec;52(12):1095-100. [Content Brief]
- [2]. Zawadzke LE, et al. Targeting the MraY and MurG bacterial enzymes for antimicrobial therapeutic intervention. Anal Biochem. 2003 Mar 15;314(2):243-52. [Content Brief]
Keywords
