26057-70-5
Chemical Structure
(±)-Avenaciolide
- CAS. Nr.: 26057-70-5
- Formula:C15H22O4
- Molecular Weight:266.33
IUPAC Name: (1S,2S,3R,5S)-3-(7-amino-5-((propyl-d7)thio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-(2-(3,4-difluorophenyl)cyclopropoxy)ethoxy)cyclopentane-1,2-diol
InChIKey: GSTQYRQXFPSWSH-AVGNSLFASA-N
SMILES: CCCCCCCC[C@H]1[C@@]2([H])[C@@](OC(C2=C)=O)([H])C(O1)=O
Biological Activity: Avenaciolide is an antifungal bis-γ-lactone found in Aspergillus avenaceus. Avenaciolide has also antibacterial action. Avenaciolide is a specific inhibitor of glutamate transport in rat liver mitochondria. Avenaciolide interferes with the ability of ADP to stimulate the rate of glutamate oxidation[1][2].
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(±)-Avenaciolide | Avenaciolide is an antifungal bis-γ-lactone found in Aspergillus avenaceus. Avenaciolide has also antibacterial action. Avenaciolide is a specific inhibitor of glutamate transport in rat liver mitochondria. Avenaciolide interferes with the ability of ADP to stimulate the rate of glutamate oxidation. | |||||||||||||||||||||
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References
- [1]. Castelo-Branco PA, et al. Synthesis and antifungal activity of aromatic bis-gamma-lactones analogous to avenaciolide. Chem Biodivers. 2007;4(12):2745-2754. [Content Brief]
- [2]. McGivan JD, Chappell JB. Avenaciolide: a specific inhibitor of glutamate transport in rat liver mitochondria. Biochem J. 1970;116(4):37P-38P. [Content Brief]
