26112-88-9
Chemical Structure
2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid
Synonym(s): PNP-α-NeuNAc
- CAS No.: 26112-88-9
- Formula:C17H22N2O11
- Molecular Weight:430.36
IUPAC Name: (2S,4S,5R,6R)-5-acetamido-4-hydroxy-2-(4-nitrophenoxy)-6-((1R,2R)-1,2,3-trihydroxypropyl)tetrahydro-2H-pyran-2-carboxylic acid
InChIKey: OICUZSPXIJAAEA-WTUOYXTGSA-N
SMILES: O=C([C@@]1(OC2=CC=C([N+]([O-])=O)C=C2)C[C@H](O)[C@@H](NC(C)=O)[C@H]([C@H](O)[C@H](O)CO)O1)O
Biological Activity: 2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid (PNP-α-NeuNAc) is a classic chromogenic substrate for neuraminidase. 2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid releases p-nitrophenol upon enzymatic hydrolysis, allowing quantification of enzyme activity and inhibitory effects via spectrophotometry. 2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid (PNP-α-NeuNAc) acts as a sialyl donor in the process of enzyme-catalyzed trans-sialylation[1][2].
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2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid | 2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid (PNP-α-NeuNAc) is a classic chromogenic substrate for neuraminidase. 2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid releases p-nitrophenol upon enzymatic hydrolysis, allowing quantification of enzyme activity and inhibitory effects via spectrophotometry. 2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid (PNP-α-NeuNAc) acts as a sialyl donor in the process of enzyme-catalyzed trans-sialylation. | |||||||||||||||||||||
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References
- [1]. Hľasová Z, et al. Methods and Current Trends in Determination of Neuraminidase Activity and Evaluation of Neuraminidase Inhibitors. Crit Rev Anal Chem. 2019;49(4):350-367. [Content Brief]
- [2]. Guo Y, et al. A Pasteurella multocida sialyltransferase displaying dual trans-sialidase activities for production of 3'-sialyl and 6'-sialyl glycans. J Biotechnol. 2014 Jan 20;170:60-7. [Content Brief]
