265989-44-4
265989-44-4
Chemical Structure
4-Hydroxy atorvastatin hemicalcium
- CAS No.: 265989-44-4
- Formula:C33H35FN2O6.1/2Ca
- Molecular Weight:594.68
SMILES: O[C@@H](C[C@@H](O)CC(O)=O)CCN1C(C(C=C2)=CC=C2F)=C(C3=CC=CC=C3)C(C(NC(C=C4)=CC=C4O)=O)=C1C(C)C.[1/2].[Ca]
Biological Activity: 4-Hydroxy atorvastatin hemicalcium is a metabolite of Atorvastatin (HY-B0589). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form 4-hydroxy atorvastatin[1][2].
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4-Hydroxy atorvastatin hemicalcium | 96.19% | 4-Hydroxy atorvastatin hemicalcium is a metabolite of Atorvastatin (HY-B0589). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form 4-hydroxy atorvastatin. | ||||||||||||||||||||
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References
- [1]. van Dam M, et al. Long term efficacy and safety of atorvastatin in the treatment of severe type III and combined dyslipidaemia. Heart. 2002;88(3):234-238. [Content Brief]
- [2]. Diabetes Atorvastin Lipid Intervention (DALI) Study Group. The effect of aggressive versus standard lipid lowering by atorvastatin on diabetic dyslipidemia: the DALI study: a double-blind, randomized, placebo-controlled trial in patients with type 2 diabetes and diabetic dyslipidemia. Diabetes Care. 2001;24(8):1335-1341. [Content Brief]
Keywords
