2702297-24-1
Chemical Structure
FGTI-2734 mesylate
- CAS No.: 2702297-24-1
- Formula:C27H35FN6O5S2
- Molecular Weight:606.73
IUPAC Name: N-(2-((4-cyano-2-fluorophenyl)((1-methyl-1H-imidazol-5-yl)methyl)amino)ethyl)-N-(cyclohexylmethyl)pyridine-2-sulfonamide methanesulfonate
InChIKey: CVSSKDKRVCBPOV-UHFFFAOYSA-N
SMILES: OS(=O)(C)=O.O=S(C1=NC=CC=C1)(N(CCN(C2=CC=C(C#N)C=C2F)CC3=CN=CN3C)CC4CCCCC4)=O
Biological Activity: FGTI-2734 mesylate is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT, respectively. FGTI-2734 mesylate can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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FGTI-2734 mesylate | 99.81% | FGTI-2734 mesylate is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT, respectively. FGTI-2734 mesylate can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors. | ||||||||||||||||||||
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Keywords
