2711810-41-0
Chemical Structure
DNA-PK-IN-6
- CAS No.: 2711810-41-0
- Formula:C19H21N7O
- Molecular Weight:363.42
IUPAC Name: (12E,35E)-17,37-dimethyl-13,17,18,19-tetrahydro-12H-2-aza-1(2,9)-purina-3(6,3)-imidazo[1,2-a]pyridinacyclooctaphan-18-one
InChIKey: DXOSNFFQQVJOOZ-UHFFFAOYSA-N
SMILES: O=C1N(C)C2=C(N3)N1CCCCCC4=CN=C(C=C5C)N4C=C5/N=C3/N=C2
Biological Activity: DNA-PK-IN-6 is a potent inhibitor of DNA-PK. DNA-PK-IN-6 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-6 enhances the sensitivity of tumor tissues to radiotherapy, overcomes the problem of agent resistance, and enhances the inhibitory effect on a variety of solid tumors and hematological tumors (extracted from patent WO2021197159A1, compound 6)[1].
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DNA-PK-IN-6 | DNA-PK-IN-6 is a potent inhibitor of DNA-PK. DNA-PK-IN-6 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-6 enhances the sensitivity of tumor tissues to radiotherapy, overcomes the problem of agent resistance, and enhances the inhibitory effect on a variety of solid tumors and hematological tumors (extracted from patent WO2021197159A1, compound 6). | |||||||||||||||||||||
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