2718170-45-5
Chemical Structure
RECQL5-IN-1
- CAS No.: 2718170-45-5
- Formula:C25H18F6N4O2S
- Molecular Weight:552.49
IUPAC Name: tert-butyl ((3S,4R)-4-hydroxy-2-oxopyrrolidin-3-yl)carbamate
InChIKey: BHTXRKYKSWDTRG-FQEVSTJZSA-N
SMILES: FC(F)(F)C1=CC(C(F)(F)F)=CC(NC(N[C@@H](C2=CC=CC=C2)C3=NN=C(SCC4=CC=CC=C4)O3)=O)=C1
Biological Activity: RECQL5-IN-1 (Compound 4a) acts as an orally effective RECQL5 inhibitor (targeting both enzymatic and nonenzymatic domain). RECQL5-IN-1 is a potent inhibitor of RECQL5 helicase activity (IC50=46.3 nM), stabilizes the interaction between RECQL5-RAD51 proteins, causes RAD51 aggregation and homologous recombination repair (HRR) inhibition, thereby exhibiting selective cytotoxicity in RECQL5-expressing cancer cells[1].
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RECQL5-IN-1 | 98.40% | RECQL5-IN-1 (Compound 4a) acts as an orally effective RECQL5 inhibitor (targeting both enzymatic and nonenzymatic domain). RECQL5-IN-1 is a potent inhibitor of RECQL5 helicase activity (IC50=46.3 nM), stabilizes the interaction between RECQL5-RAD51 proteins, causes RAD51 aggregation and homologous recombination repair (HRR) inhibition, thereby exhibiting selective cytotoxicity in RECQL5-expressing cancer cells. | ||||||||||||||||||||
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Keywords
