2719690-99-8
2719690-99-8
Chemical Structure
AZ7550-d5
- CAS No.: 2719690-99-8
- Formula:C27H26D5N7O2
- Molecular Weight:490.61
IUPAC Name: N-(4-methoxy-2-(methyl(2-(methylamino)ethyl)amino)-5-((4-(1-(methyl-d3)-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide-3,3-d2
InChIKey: ZROCWKZRGJYPTG-PCZBYHPYSA-N
SMILES: O=C(NC1=CC(NC2=NC=CC(C3=CN(C([2H])([2H])[2H])C4=C3C=CC=C4)=N2)=C(OC)C=C1N(C)CCNC)/C=C([2H])\[2H]
Biological Activity: AZ7550-d5 is the deuterium labeled AZ7550?(HY-B0794). AZ7550, an active metabolite of Osimtinib (AZD9291; HY-15772), inhibits the activity of?IGF1R?with an?IC50?of 1.6 μM[1][2].
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AZ7550-d5 | AZ7550-d5 is the deuterium labeled AZ7550?(HY-B0794). AZ7550, an active metabolite of Osimtinib (AZD9291; HY-15772), inhibits the activity of?IGF1R?with an?IC50?of 1.6 μM. | |||||||||||||||||||||
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AZ7550 | 97.09% | AZ7550 is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM. | ||||||||||||||||||||
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References
- [1]. Yonggang Meng, et al. Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer. J Med Chem. 2021 Jan 28;64(2):925-937. [Content Brief]
- [2]. Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57(20):8249-67. [Content Brief]
