2733721-10-1
2733721-10-1
Chemical Structure
4-Methyl-2-(1-piperidinyl)-quinoline-d10
- CAS No.: 2733721-10-1
- Formula:C15H8D10N2
- Molecular Weight:236.38
InChIKey: USYRQXDHKXGTCK-VHPHYHOGSA-N
SMILES: [2H]C1(C([2H])(C([2H])(C([2H])(C([2H])(N1C2=NC3=C(C=CC=C3)C(C)=C2)[2H])[2H])[2H])[2H])[2H]
Biological Activity: 4-Methyl-2-(1-piperidinyl)-quinoline-d10 is the deuterium labeled ML204 (HY-12949). ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels[1][2].
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4-Methyl-2-(1-piperidinyl)-quinoline-d10 | 4-Methyl-2-(1-piperidinyl)-quinoline-d10 is the deuterium labeled ML204 (HY-12949). ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels. | |||||||||||||||||||||
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ML204 | 98.45% | ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels. | ||||||||||||||||||||
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References
- [1]. Miller M, et al. Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem. 2011 Sep 23;286(38):33436-46. [Content Brief]
- [2]. Miller MR, et al. Novel Chemical Inhibitor of TRPC4 Channels. Probe Reports from the NIH Molecular Libraries Program [Internet]. [Content Brief]
