2749427-97-0
2749427-97-0
Chemical Structure
Acotiamide-d6
Synonym(s): Z-338-d6 free base; YM443-d6 free base
- CAS No.: 2749427-97-0
- Formula:C21H24D6N4O5S
- Molecular Weight:456.59
IUPAC Name: N-(2-(diisopropylamino)ethyl)-2-(2-hydroxy-4,5-bis(methoxy-d3)benzamido)thiazole-4-carboxamide
InChIKey: TWHZNAUBXFZMCA-SCPKHUGHSA-N
SMILES: O=C(C1=CSC(NC(C2=CC(OC([2H])([2H])[2H])=C(OC([2H])([2H])[2H])C=C2O)=O)=N1)NCCN(C(C)C)C(C)C
Biological Activity: Acotiamide-d6 is a deuterium labeled Acotiamide. Acotiamide is an orally active and first-in-class gastroprokinetic agent for the treatment of functional dyspepsia[1][2].
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Acotiamide-d6 | Acotiamide-d6 is a deuterium labeled Acotiamide. Acotiamide is an orally active and first-in-class gastroprokinetic agent for the treatment of functional dyspepsia. | |||||||||||||||||||||
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Acotiamide-d4 | Acotiamide-d4 (Z-338 (free base)-d4) is deuterium labeled Acotiamide. Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory. | |||||||||||||||||||||
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Acotiamide | 99.92% | Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory. | ||||||||||||||||||||
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References
- [1]. Nowlan ML, et al. Acotiamide: first global approval. Drugs. 2013 Aug;73(12):1377-83. [Content Brief]
- [2]. Attia KAM, et al. Spectrofluorimetric determination of acotiamide hydrochloride trihydrate in the presence of its oxidative degradation product. Luminescence. 2018 Jun;33(4):806-811. [Content Brief]
Keywords
