2753651-10-2
2753651-10-2
Chemical Structure
GDC-2992
Synonym(s): RO7656594
- No. CAS: 2753651-10-2
- Formula:C45H51ClN8O5
- Molecular Weight:819.39
InChIKey: PAELKDHSDBUTGE-SCBUQILPSA-N
SMILES: N#CC1=CC=C(O[C@H]2C(C)(C)[C@H](NC(C3=CC=C(N4CCC(CN5CCN(C6=CC(C=NN([C@@H]7C(NC(CC7)=O)=O)C8=O)=C8C=C6)CC5)CC4)C=C3)=O)C2(C)C)C=C1Cl
Biological Activity: GDC-2992 (Compound 28A) is an orally bioavailable androgen receptor (AR) PROTAC degrader. GDC-2992 degrads AR with a DC50 value of 2.7 nM and inhibits proliferation with an IC50 valude of 9.7 nM in VCaPcells. GDC-2992 can be used for prostatic cancer study[1].
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GDC-2992 | 99.38% | GDC-2992 (Compound 28A) is an orally bioavailable androgen receptor (AR) PROTAC degrader. GDC-2992 degrads AR with a DC50 value of 2.7 nM and inhibits proliferation with an IC50 valude of 9.7 nM in VCaPcells. GDC-2992 can be used for prostatic cancer study. | ||||||||||||||||||||
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