2756581-81-2
2756581-81-2
Chemical Structure
IDOR-1104-0086
- CAS No.: 2756581-81-2
- Formula:C15H15F5N2O
- Molecular Weight:334.28
SMILES: O=C(NCC1=CC=CC(C(F)(F)F)=C1)NC2(C3)CC3(C(F)F)C2
Biological Activity: IDOR-1104-0086 is an orally active Kv7 potassium channel opener with an EC50 of 210 nM that can cross blood-brain barrier. IDOR-1104-0086 displays strong selectivity against the hERG channel with an IC20 of 25 μM. IDOR-1104-0086 exhibits efficacy in two rodent models of epilepsy and a favorable tolerability profile. IDOR-1104-0086 can used for the study of epilepsy[1].
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IDOR-1104-0086 | 98.98% | IDOR-1104-0086 is an orally active Kv7 potassium channel opener with an EC50 of 210 nM that can cross blood-brain barrier. IDOR-1104-0086 displays strong selectivity against the hERG channel with an IC20 of 25 μM. IDOR-1104-0086 exhibits efficacy in two rodent models of epilepsy and a favorable tolerability profile. IDOR-1104-0086 can used for the study of epilepsy. | ||||||||||||||||||||
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References
Keywords
