IDOR-1104-0086
Based on 1 Customer Validation
IDOR-1104-0086 is an orally active Kv7 potassium channel opener with an EC50 of 210 nM that can cross blood-brain barrier. IDOR-1104-0086 displays strong selectivity against the hERG channel with an IC20 of 25 μM. IDOR-1104-0086 exhibits efficacy in two rodent models of epilepsy and a favorable tolerability profile. IDOR-1104-0086 can used for the study of epilepsy.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98.98%
- No. CAS: 2756581-81-2
- Fòrmula: C15H15F5N2O
- Peso molecular:334.28
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Almacenamiento:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
[1]|
Kv7 250 nM (EC50) |
In Vitro
IDOR-1104-0086 (Compound 31) effectively inhibits pathological calcium oscillations in the primary cortical neuron-schizophrenia cell co-culture system of rats with IC50s of 188 nM ' and 228 nM (20 min)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Audiogenic seizure-sensitive model of generalized convulsive seizures established in male juvenile DBA/2J mice (22-24 days old)[1]
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Dosage:10 mg/kg
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Administration:Oral administration (p.o.), single dose
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Result:Induced almost full protection from the generalized tonic-clonic seizure in the AGS mouse model.
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Animal Model:Amygdala-kindling rat Model established in adult male Wistar rats (body weight 300-350g)[1]
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Dosage:10 and 30 mg/kg
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Administration:Oral administration (p.o.), single dose
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Result:Displayed the inhibition of the bilateral forelimb clonus and facial myoclonic twitches without behavioral side effects.
Chemical Information
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No. CAS 2756581-81-2
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Appearance Solid
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Peso molecular 334.28
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Fòrmula C15H15F5N2O
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Color White to off-white
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SMILES
O=C(NCC1=CC=CC(C(F)(F)F)=C1)NC2(C3)CC3(C(F)F)C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (299.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9915 mL | 14.9575 mL | 29.9150 mL | 74.7876 mL |
| 5 mM | 0.5983 mL | 2.9915 mL | 5.9830 mL | 14.9575 mL | |
| 10 mM | 0.2992 mL | 1.4958 mL | 2.9915 mL | 7.4788 mL | |
| 15 mM | 0.1994 mL | 0.9972 mL | 1.9943 mL | 4.9858 mL | |
| 20 mM | 0.1496 mL | 0.7479 mL | 1.4958 mL | 3.7394 mL | |
| 25 mM | 0.1197 mL | 0.5983 mL | 1.1966 mL | 2.9915 mL | |
| 30 mM | 0.0997 mL | 0.4986 mL | 0.9972 mL | 2.4929 mL | |
| 40 mM | 0.0748 mL | 0.3739 mL | 0.7479 mL | 1.8697 mL | |
| 50 mM | 0.0598 mL | 0.2992 mL | 0.5983 mL | 1.4958 mL | |
| 60 mM | 0.0499 mL | 0.2493 mL | 0.4986 mL | 1.2465 mL | |
| 80 mM | 0.0374 mL | 0.1870 mL | 0.3739 mL | 0.9348 mL | |
| 100 mM | 0.0299 mL | 0.1496 mL | 0.2992 mL | 0.7479 mL |
IDOR-1104-0086 Related Classifications
HY-175668 Related Classifications
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