2758062-71-2
Chemical Structure
Axl-IN-22
- CAS. Nr.: 2758062-71-2
- Formula:C34H35F2N9O3
- Molecular Weight:655.70
InChIKey: KPQGYUFQGKQTDF-UHFFFAOYSA-N
SMILES: CC(F)(C(N1CCC(CC1)C2=CC(C3=CC=C(C=C3F)NC(C4=C5CCCCN5N(C4=O)C6=NC=CC=C6)=O)=C7C(N)=NC=NN27)=O)C
Biological Activity: Axl-IN-22 is a selective, orally active dual inhibitor of AXL/MER, with IC50 values of 13 nM and 10 nM, respectively. Axl-IN-22 functionally inhibits AXL kinase activity, including ligand-independent autophosphorylation, and blocks the downstream PI3K/AKT signaling pathway, with excellent selectivity over TYRO3, IGF1R and INSR. Axl-IN-22 inhibits tumor growth in vivo and produces a synergistic effect when combined with anti-PD-1 antibody. Axl-IN-22 can be used in studies related to malignant tumors, leukemia, colon cancer and non-small cell lung cancer[1].
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Axl-IN-22 | Axl-IN-22 is a selective, orally active dual inhibitor of AXL/MER, with IC50 values of 13 nM and 10 nM, respectively. Axl-IN-22 functionally inhibits AXL kinase activity, including ligand-independent autophosphorylation, and blocks the downstream PI3K/AKT signaling pathway, with excellent selectivity over TYRO3, IGF1R and INSR. Axl-IN-22 inhibits tumor growth in vivo and produces a synergistic effect when combined with anti-PD-1 antibody. Axl-IN-22 can be used in studies related to malignant tumors, leukemia, colon cancer and non-small cell lung cancer. | |||||||||||||||||||||
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