2758802-18-3
2758802-18-3
Chemical Structure
HSD17B13-IN-21
- CAS No.: 2758802-18-3
- Formula:C21H18Cl2N2O4S
- Molecular Weight:465.35
InChIKey: QJMCYBURPYMYKK-UHFFFAOYSA-N
SMILES: O=C(C1=CC(Cl)=C(O)C=C1)NC2=C(C(NCCC3=C(OC)C=CC=C3)=O)SC(Cl)=C2
Biological Activity: HSD17B13-IN-21 (compound 17) is a ppotent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of ＜ 0.1 μM and? ＜ 1 μM estradiol and Leukotriene B3 as substrates, respectively. HSD17B13-IN-21? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis)[1].
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HSD17B13-IN-21 | HSD17B13-IN-21 (compound 17) is a ppotent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of ＜ 0.1 μM and? ＜ 1 μM estradiol and Leukotriene B3 as substrates, respectively. HSD17B13-IN-21? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis). | |||||||||||||||||||||
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References
Keywords
