2760511-91-7
Chemical Structure
XP5
- CAS No.: 2760511-91-7
- Formula:C19H25N3O5S
- Molecular Weight:407.48
IUPAC Name: 2-(2,4-dimethoxyphenyl)-N-(7-(hydroxyamino)-7-oxoheptyl)thiazole-5-carboxamide
InChIKey: KPMUSOQFDJSLDU-UHFFFAOYSA-N
SMILES: COC1=CC=C(C(OC)=C1)C2=NC=C(S2)C(NCCCCCCC(NO)=O)=O
Biological Activity: XP5 is a potent, orally active HDAC6 inhibitor with an IC50 of 31 nM. XP5 displays high antiproliferative activity against various cancer cell lines including the HDACi-resistant YCC3/7 gastric cancer cells (IC50=0.16-2.31 μM). XP5 enhances antitumor immunity when combined with a PD-L1 inhibitor in melanoma[1].
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XP5 | XP5 is a potent, orally active HDAC6 inhibitor with an IC50 of 31 nM. XP5 displays high antiproliferative activity against various cancer cell lines including the HDACi-resistant YCC3/7 gastric cancer cells (IC50=0.16-2.31 μM). XP5 enhances antitumor immunity when combined with a PD-L1 inhibitor in melanoma. | |||||||||||||||||||||
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Keywords
