2762675-42-1
Chemical Structure
LasB-IN-3
- CAS No.: 2762675-42-1
- Formula:C18H21ClNO4P
- Molecular Weight:381.79
InChIKey: QFRMEIBQCNKVJN-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(C=C1)C2=CC=C(C=C2)Cl)C(CC(C)C)P(O)(O)=O
Biological Activity: LasB-IN-3 is a protease elastase (LasB) inhibitor of Pseudomonas aeruginosa with an IC50 value of 8.5 nM. LasB-IN-3 shows an IC50 of 58.9 nM for the Met128Val mutant. LasB-IN-3 binds to active sites of wild-type and Met128Val mutant LasB, coordinates zinc ions, forms hydrogen bonds and CH-π interactions, and inhibits LasB proteolytic activity. LasB-IN-3 increases survival rate in LasB-induced acute lung injury mice models. LasB-IN-3 can be used for the research of Pseudomonas aeruginosa infection[1].
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LasB-IN-3 | LasB-IN-3 is a protease elastase (LasB) inhibitor of Pseudomonas aeruginosa with an IC50 value of 8.5 nM. LasB-IN-3 shows an IC50 of 58.9 nM for the Met128Val mutant. LasB-IN-3 binds to active sites of wild-type and Met128Val mutant LasB, coordinates zinc ions, forms hydrogen bonds and CH-π interactions, and inhibits LasB proteolytic activity. LasB-IN-3 increases survival rate in LasB-induced acute lung injury mice models. LasB-IN-3 can be used for the research of Pseudomonas aeruginosa infection. | |||||||||||||||||||||
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