2765539-59-9
2765539-59-9
Chemical Structure
LSN3160440
- CAS No.: 2765539-59-9
- Formula:C27H27Cl2N3O
- Molecular Weight:480.43
IUPAC Name: 1-((R)-1-(2,6-dichloro-3-methoxyphenyl)ethyl)-6-(2-((R)-piperidin-2-yl)phenyl)-1H-benzo[d]imidazole
InChIKey: YFCMSHPEVDOMQA-VGOFRKELSA-N
SMILES: C[C@H](C1=C(C(OC)=CC=C1Cl)Cl)N2C3=CC(C4=C([C@H]5CCCCN5)C=CC=C4)=CC=C3N=C2
Biological Activity: LSN3160440 is an allosteric modulator of GLP-1R, which acts as a protein–protein interaction (PPI) stabilizer or molecular glue to assist in the adhesion of inactive GLP-1 (9-36) NH2 on GLP-1R[1][2].
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LSN3160440 | 98.08% | LSN3160440 is an allosteric modulator of GLP-1R, which acts as a protein–protein interaction (PPI) stabilizer or molecular glue to assist in the adhesion of inactive GLP-1 (9-36) NH2 on GLP-1R. | ||||||||||||||||||||
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References
- [1]. Hui-Jun Liao, et al. Investigating Potential GLP-1 Receptor Agonists in Cyclopeptides from Pseudostellaria heterophylla, Linum usitatissimum, and Drymaria diandra, and Peptides Derived from Heterophyllin B for the Treatment of Type 2 Diabetes: An In Silico Study. Metabolites. 2022 Jun 15;12(6):549. [Content Brief]
- [2]. Hongyu Wu, et al. Molecular glues modulate protein functions by inducing protein aggregation: A promising therapeutic strategy of small molecules for disease treatment. Acta Pharm Sin B. 2022 Sep;12(9):3548-3566. [Content Brief]
Keywords
