LSN3160440
Based on 1 Customer Validation
LSN3160440 is an allosteric modulator of GLP-1R, which acts as a protein–protein interaction (PPI) stabilizer or molecular glue to assist in the adhesion of inactive GLP-1 (9-36) NH2 on GLP-1R.
For research use only. We do not sell to patients.
- Purity: 98.08%
- CAS No.: 2765539-59-9
- Formula: C27H27Cl2N3O
- Molecular Weight:480.43
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
LSN3160440 binds between the TM1 and TM2 interfaces of GLP-1R, and the benzimidazole group of LSN3160440 interacts with GLP-1R in a variety of ways, such as van der Waals contacts with Leu142, π‒π stacking with Tyr145, and frequent water bridging with Lys202[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2765539-59-9
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Appearance Solid
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Molecular Weight 480.43
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Formula C27H27Cl2N3O
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Color White to off-white
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SMILES
C[C@H](C1=C(C(OC)=CC=C1Cl)Cl)N2C3=CC(C4=C([C@H]5CCCCN5)C=CC=C4)=CC=C3N=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Hui-Jun Liao, et al. Investigating Potential GLP-1 Receptor Agonists in Cyclopeptides from Pseudostellaria heterophylla, Linum usitatissimum, and Drymaria diandra, and Peptides Derived from Heterophyllin B for the Treatment of Type 2 Diabetes: An In Silico Study. Metabolites. 2022 Jun 15;12(6):549. [Content Brief]
[2]. Hongyu Wu, et al. Molecular glues modulate protein functions by inducing protein aggregation: A promising therapeutic strategy of small molecules for disease treatment. Acta Pharm Sin B. 2022 Sep;12(9):3548-3566. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LSN3160440 Related Classifications
HY-153193 Related Classifications
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