2771312-16-2
Chemical Structure
ATX inhibitor 12
- CAS No.: 2771312-16-2
- Formula:C30H34FN5O2
- Molecular Weight:515.62
IUPAC Name: 1-(2-ethyl-6-(4-((4-hydroxypiperidin-1-yl)methyl)phenyl)-8-methylimidazo[1,2-a]pyridin-3-yl)-3-(4-fluorobenzyl)urea
InChIKey: FEXSQVDKSHZBNQ-UHFFFAOYSA-N
SMILES: CCC1=C(N2C=C(C=C(C2=N1)C)C3=CC=C(C=C3)CN4CCC(CC4)O)NC(NCC5=CC=C(C=C5)F)=O
Biological Activity: ATX inhibitor 12 (compound 20) is an orally active and potent ATX (autotaxin) inhibitor, with an IC50 of 1.72 nM. ATX inhibitor 12 effectively alleviates lung structural damage with fewer fibrotic lesions at an oral dose of 60 mg/kg in C57Bl/6J mice. ATX inhibitor 12 can be uesd for idiopathic pulmonary fibrosis (IPF) research[1].
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ATX inhibitor 12 | ATX inhibitor 12 (compound 20) is an orally active and potent ATX (autotaxin) inhibitor, with an IC50 of 1.72 nM. ATX inhibitor 12 effectively alleviates lung structural damage with fewer fibrotic lesions at an oral dose of 60 mg/kg in C57Bl/6J mice. ATX inhibitor 12 can be uesd for idiopathic pulmonary fibrosis (IPF) research. | |||||||||||||||||||||
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Keywords
