2773345-67-6
Chemical Structure
KZL-064
- CAS No.: 2773345-67-6
- Formula:C17H15F3N4O
- Molecular Weight:348.32
InChIKey: UUSILEPMRTYMKF-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1N)N(C2=NC(C(F)(F)F)=NC3=CC=CC=C32)C
Biological Activity: KZL-064 is an orally active HDAC1 ligand that directly binds to HDAC1. KZL-064 inhibits the proliferation, migration, and invasion of hepatocellular carcinoma cells, and induces apoptosis and G2/M phase cell cycle arrest. The antiproliferative, proapoptotic, and cell cycle regulatory effects of KZL-064 are partially dependent on HDAC1, while its inhibitory effects on migration and invasion also involve HDAC1-independent mechanisms. KZL-064 is applicable to hepatocellular carcinoma research[1].
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KZL-064 | KZL-064 is an orally active HDAC1 ligand that directly binds to HDAC1. KZL-064 inhibits the proliferation, migration, and invasion of hepatocellular carcinoma cells, and induces apoptosis and G2/M phase cell cycle arrest. The antiproliferative, proapoptotic, and cell cycle regulatory effects of KZL-064 are partially dependent on HDAC1, while its inhibitory effects on migration and invasion also involve HDAC1-independent mechanisms. KZL-064 is applicable to hepatocellular carcinoma research. | |||||||||||||||||||||
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