2791417-66-6
2791417-66-6
Chemical Structure
MTX-531
- CAS No.: 2791417-66-6
- Formula:C22H20ClN5O2S
- Molecular Weight:453.94
InChIKey: LPJIZDSOUGHTNB-CQSZACIVSA-N
SMILES: ClC1=C(NS(=O)(C)=O)C=C(C2=CC3=C(N=CN=C3N[C@@H](C4=CC=CC=C4)C)C=C2)C=N1
Biological Activity: MTX-531 is an oral drug that inhibits EGFR (with an IC50 of 14.7 nM) and PI3K (with IC50 values of 6.4, 233, 8.3, and 1.1 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ respectively), and it has anti-tumor effects. MTX-531 also acts as a weak agonist of PPARγ, with an IC50 of 2.5 µM, helping to alleviate hyperglycemia induced by PI3K inhibitors[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MTX-531 | 99.87% | MTX-531 is an oral drug that inhibits EGFR (with an IC50 of 14.7 nM) and PI3K (with IC50 values of 6.4, 233, 8.3, and 1.1 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ respectively), and it has anti-tumor effects. MTX-531 also acts as a weak agonist of PPARγ, with an IC50 of 2.5 µM, helping to alleviate hyperglycemia induced by PI3K inhibitors. | ||||||||||||||||||||
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References
Keywords
