2847092-41-3
Chemical Structure
FGFR-IN-10
- CAS No.: 2847092-41-3
- Formula:C28H30FN9O2
- Molecular Weight:543.60
IUPAC Name: 1-((2R,6R)-4-(5-(3-fluoro-4-((4-methylpyrimidin-2-yl)oxy)phenyl)-2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-2,6-dimethylpiperazin-1-yl)prop-2-en-1-one
InChIKey: CZZNJNOCNVJYEP-RTBURBONSA-N
SMILES: FC(C=C1C2=CN=C(N=C2N3C[C@H](N([C@@H](C3)C)C(C=C)=O)C)NC4=CN(N=C4)C)=C(C=C1)OC5=NC=CC(C)=N5
Biological Activity: FGFR-IN-10 is an orally active inhibitor of FGFR and Cytochrome P450 (CYPs). FGFR-IN-10 inhibits wide type and V564F mutant FGFR2 with IC50s of 104.1 nM and 43.6 nM, respectively. FGFR-IN-10 also inhibits CYPs with IC50s of 3.33 μM (CYP2C9), 18.75 μM (CYP2C19), 4.34 μM (CYP2CD6), and 0.69 μM (CYP3A4), respectively[1].
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FGFR-IN-10 | FGFR-IN-10 is an orally active inhibitor of FGFR and Cytochrome P450 (CYPs). FGFR-IN-10 inhibits wide type and V564F mutant FGFR2 with IC50s of 104.1 nM and 43.6 nM, respectively. FGFR-IN-10 also inhibits CYPs with IC50s of 3.33 μM (CYP2C9), 18.75 μM (CYP2C19), 4.34 μM (CYP2CD6), and 0.69 μM (CYP3A4), respectively. | |||||||||||||||||||||
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Keywords
